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文摘
摘要目的:确定儿童的比例和特点呈现与儿童失神癫痫(CAE)不服用的抗癫痫药物(aed),控制发作过去一年的长期随访。方法:发现病例,集中的脑电图记录新斯科舍省允许识别与典型的CAE诊断的儿童在1977年和1985年之间。后续在1994年到1995年。结果:与CAE的81名儿童,72(89%)联系跟进。在癫痫发病平均年龄为5.7岁(范围1到14年),在随访20.4年(范围、12 - 31年)。47个(65%)在缓解。12人(17%)没有采取aed但仍有癫痫发作。13(18%)正在aed;五个是控制发作过去一年(在四个试验没有aed之前失败了)。总数的百分之十五人群已经发展到青少年肌阵挛癫痫(期刊)。 Multiple clinical and EEG factors were examined as predictors of outcome. Factors predicting no remission (p < 0.05) included cognitive difficulties at diagnosis, absence status prior to or during AED treatment, development of generalized tonic clonic or myoclonic seizures after onset of AEDs, abnormal background on initial EEG, and family history of generalized seizures in first-degree relatives. Conclusions: Only 65% of children presenting with CAE had remission of their epilepsy. Forty-four percent of those without remission had developed JME. At the time of diagnosis, remission is difficult to predict accurately in most patients. However, development of generalized tonic-clonic seizures or myoclonic seizures during AED treatment is ominous, predicting both lack of remission of CAE and progression to JME.
首页神经学1996;47:912 - 918
- 版权1996年Advanstar通信公司。
