神经心理学的意义领域的高信号强度对大脑核磁共振成像的神经纤维瘤患儿

文摘

儿童神经纤维瘤(NF), 40%有一个认知或学习障碍。大约60%也异常高信号强度T的地区₂三大脑核磁共振成像。这些hyperintensities协会和神经心理状态还没有完全理解。我们管理的一系列神经心理测试和一个标准的临床磁共振成像来确定hyperintensity存在的影响,数量和位置在84名儿童认知状态(8到16年)和NF 1型。这些孩子接受标准临床磁共振成像扫描仪使用通用电气1.5特斯拉(除了一个孩子谁是检查1.0特斯拉扫描仪)。我们进行了三种类型的分析:Hyperintensity存在与否。- - - - - -- - - - - -Scores of children with (55%) and without hyperintensities (45%) were compared using t tests. No statistically significant differences between groups in intellectual functioning or any neuropsychological variable were found. Number of hyperintensities--The number of hyperintensity locations per child ranged from one to five (mean = 2.22). Pearson correlations revealed no significant association between the number of hyperintensities and neuropsychological performance. Location of hyperintensities--In four of the five locations studied, no statistically significant differences were found between scores of children with a hyperintensity in an area and those with one elsewhere. However, mean scores for IQ, Memory, Motor, Distractibility, and Attention domains for children with hyperintensities in the thalamus were significantly lower than scores for those with hyperintensities elsewhere. These results suggest that the simple presence or absence of hyperintensities, or their total number, is not as important as their anatomic location for detecting their relationship with neuropsychological status. Taking location into account, hyperintensities in the cerebral hemispheres, basal ganglia, brainstem, or cerebellum seem to have no impact on neuropsychological functioning, whereas hyperintensities in the thalamus do.

首页神经学1996;46:1660 - 1668