这篇文章需要订阅查看全文。如果你有一个订阅你可以用下面的登录表单查看文章。这篇文章也可以购买。
文摘
硬膜外脊髓疾病(ESCD),一个罕见的并发症系统性非霍奇金淋巴瘤(NHL),可能发生在诊断或复发,通常是接受放疗,或很少手术减压。我们回顾性分析了140例胸NHL (IG-NHL)治疗dose-intense协议使用阿霉素、长春新碱、大剂量环磷酰胺(NHL-15)。有七集ESCD 6个(4.3%)病人。五期无症状表现;一个病人有背痛、腿麻木和刺痛;和一个神经根疼痛和轻微的腿的弱点。没有CSF的恶性细胞。一个病人接受高剂量地塞米松椎板切除术后进行诊断性活检;否则,使用地塞米松在化疗之前只作为一种止吐药。患者在诊断ESCD收到计划的NHL-15化疗作为治疗ESCD,和那些发达ESCD NHL-15处理复发方案包含异环磷酰胺,卡铂,依托泊苷(冰)。 After chemotherapy alone, five of seven episodes showed radiographic resolution of ESCD and improvement of neurologic deficits. One patient received consolidation radiotherapy (2,700 cGy) to the spine after ICE for relapsed ESCD and had a complete response. One patient had progression of systemic lymphoma and ESCD despite chemotherapy. These data suggest that chemotherapy may be effective as initial treatment of ESCD in IG-NHL and may reduce the potential complications of spinal surgery and radiotherapy.
首页神经学1996;46:1543 - 1547
- 版权1996年Advanstar通信公司。
