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文摘
文章摘要100连续格林-巴利综合征患者,我们评估肝功能入院时和在固定间隔后静脉注射免疫球蛋白(IgIV)或血浆置换(PE)治疗。入院时,38%显示血浆丙氨酸转氨酶升高,γ谷酰基转移酶升高,或超过正常上限的1.5倍。10这些患者血清学的最近的巨细胞病毒感染的证据。其余28患者对其他已知的不利原因引起的肝脏损伤,包括巴尔病毒感染或甲型肝炎,B和C;酗酒;肝毒素的药物;最近的手术;和并发肝脏疾病。在医院对照组100连续蛛网膜下腔出血患者,只有5原因不明的入学肝功能障碍(p < 0.0001)。IgIV-treated组的比例升高的患者肝功能测试从35%上升到69%治疗2周后不久postadmission (p < 0.005)。 In the PE-treated group, this percentage decreased somewhat from 41% to 36% (not significant). There was also a significant rise in median plasma activity of the various liver enzymes in the IgIV group. At 1 month, however, significant difference had disappeared. At 3 and 6 months, the percentage of patients with liver function disturbances reached a significantly lower level in both treatment groups compared with the time of admission. We concluded that many patients with Guillain-Barre syndrome had mild liver function disturbances without obvious cause. In addition, IgIV treatment was associated with mild transient liver function disturbances through an unknown mechanism.
首页神经学1996;46:96 - 100
- 版权1996年Advanstar通信公司。
