文摘
本文处理血脑屏障(BBB)与多发性硬化症(MS)。与以下讨论的BBB女士:后期灌注利用台盼蓝;循环血清白蛋白作为常态的标记的内皮细胞紧密连接中枢神经系统;CSF白蛋白作为女士BBB的标志;体内检测BBB的改变病变女士利用电脑断层扫描的大脑;检测中枢神经系统(CNS)免疫球蛋白的从头合成有或没有一个改变BBB;利用公式来估计新创中枢神经系统免疫球蛋白合成评估公认的治疗方法。此外,建议由内存在两个交错的殖民地女士的BBB免疫细胞能合成免疫球蛋白在音乐会或独立。殖民地1由B淋巴细胞可能预编程经历抗原免疫网络的核心,这是招募从血液通过趋化性中枢神经系统。这种类型的免疫外观可以复制MS患者抗原暴露和奖励中枢神经系统与焦女士,原位合成抗体,因此传授中枢神经系统迅速super-resistance。 Colony 2 consists of resident plasma cells attributable to a persistent in situ antigenic stimulation, presumably owing to the MS antigen. Finally, since the CNS in MS has been provoked to become a type of immune organ-that is, it is able to synthesize IgG de novo—it is reasonable to propose the following: That de novo IgG in the CNSKSF, especially oligoclonal IgG, is antibody in excess of its antigen. We believe it can be used as an antibody reagent to search for the persistent antigenic stimulus present most appropriately at the periplaque edge, which might presumably turn out to be related to the cause of MS.
- 美国神经病学学会©1978首页
