Abstract
SUMMARYThe somatosensory evoked response amplitured and latency recovery functions have been determined in 11 normal subjects and 10 patients with MS. The results show [1] no difference in the amplitude recovery between the groups and [2] a significant shortening of the patient test stimulus latency at shorter interstimulus times.
These results suggest that:
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Diseased or demyelinated axons cannot effectively respond to a test stimulus that follows a conditioning stimulus by short intervals (less than 60 msec).
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The more heavily myelinated and fastest conducting fibers are selectively more affected by the demyelination process.
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The application of this method holds promise for assessing neuronal conduction in MS patients in comparison to normal subjects.
- © 1970 by the American Academy of Neurology
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