文摘
SUMMARYThe吐根碱对大鼠比目鱼肌的影响(一个红色的肌肉)和腓肠肌内侧头(相对白肌肉)。药物服用剂量为1.25毫克。每天每千克五、十或十五天。在治疗中,比目鱼肌比腓肠肌更严重的影响。损失的横条纹小比目鱼肌领域指出了第五天。十五日,20 - 90%(平均48%)比目鱼肌的纤维在一个给定的平面显示多个病灶,一些纤维和250一样宽,μ长,但只有不到10%的腓肠肌纤维偶尔显示病变的第十五天。2 - 4%的纤维在12的19控制比目鱼肌活检和1%的纤维在2 19控制腓肠肌活检也包含相同类型的小病灶。扩大和泡状核出现在治疗肌肉纤维越来越多的第五天。坏死纤维,一些正在吞噬,细长的再生纤维由十五日被发现在治疗肌肉。纵向导向的比目鱼肌hydroxyadipaldehyde-fixed标本展示减少线粒体氧化的酶活性在多个,限制区域。 These areas increased in size and number over the course of the study and some, but not all, areas also displayed loss of cross striations within their confines. Loss of cross striations was found only in regions of decreased mitochondrial enzyme activity. Under the conditions of the experiment, emetine induced pathological alterations in muscle without recognizable morphological or physiological alterations in the neural components of the motor unit.
- 美国神经病学学会©1970首页
