Abstract
SUMMARYThirty-seven aspects related to the pathophysiology of serum and CSF immunoglobulins, including electrophoresis, immunoelectron-phoresis, CSF cytomorphology, and determination of the concentration of serum and CSF immunoglobulins, were studied in 64 patients with multiple sclerosis. The studies support the assumption that in addition to the immunopathological manifestations carried by immunocompetent cells in the CNS structures of patients with multiple sclerosis, the extraneural lymphoreticular system exhibits an abnormal activity, at least during certain phases of the disease.
From our experiences in electrophoretic, immunochemical, and cytomorphological examinations of over 900 patients with different neurological diseases, no specific manifestations were observed which might allow, per se, the diagnosis of MS.
- © 1970 by the American Academy of Neurology
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Differences in Age-related Retinal and Cortical Atrophy Rates in Multiple Sclerosis
Prof. Massimo Filippi and Dr. Paolo Preziosa