2023年7月18日
;101 (3)
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慢性肾病协会与等离子体NfL和其他神经退化的生物标志物
在哥德堡H70出生队列研究
第一次出版2023年5月24日,
DOI: https://doi.org/10.1212/WNL.0000000000207419
安娜>
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
尼古拉斯·j·阿什顿
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
Henrik Zetterberg
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
Kaj Blennow
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
安娜Zettergren
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
乔尔Simren
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
托拜厄斯Skillback
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
萨拉·夏姆斯
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
Alejandra马查多
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
埃里克·韦斯特曼
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
迈克尔肖勒
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
英格玛·斯库
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
Silke Kern
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
慢性肾病协会与等离子体NfL和其他神经退化的生物标志物
在哥德堡H70出生队列研究
安娜>,Nicholas J。艾什顿,亨瑞克Zetterberg,KajBlennow,安娜Zettergren,乔尔Simren,托拜厄斯Skillback,莎拉沙姆斯,Alejandra马查多,埃里克韦斯特曼,迈克尔肖勒,英格玛·斯库,Silke克恩
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2023年7月,
101年
(3)
e277-e288;
DOI:10.1212 / WNL.0000000000207419
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文章数据和数据
数据
图2
结构磁共振成像测量和脑脊液生物标志物在参与者和慢性肾病
结构的MRI测量神经退化相关的大脑区域提出了参与者没有和CKD(模拟)。意思是皮质厚度(A),意味着侧心室体积(B),意味着海马体积(C),和白质病变总额(D)测量。脑脊液生物标记物与神经退化也分析(情况)。Aβ42/40-ratio (E), t-tau (F), p-tau (G),和CSF NfL (H)测定在参与者和慢性肾病。在小组模拟n = 744(没有CKD = 668, CKD = 76)和n = 313面板超高频(没有CKD = 287, CKD = 26)。的Mann-WhitneyU以及用于groupwise比较。NfL =光神经丝蛋白;p-tau =磷酸化τ;t-tau =总τ。
图3
P-NfL之间的关联和肾脏功能,分层CKD和痴呆
P-NfL散点图和表皮生长因子受体的研究参与者(n = 743, 1例外是不包括在图中,而是包含在统计,n = 744),与线性回归曲线分层CKD状态(没有CKD, n = 668, CKD, n = 76) (A),肾功能测量表皮生长因子受体(B)和P-NfL水平(C)在参与者认知障碍(CDR = 0),分层的CKD状态(没有CKD, n = 540, CKD, n = 62)、和参与者与痴呆和正常肾功能(n = 9)。在图上进行线性回归直线untransformed P-NfL值允许临床相关数据的显示面板。Groupwise与克鲁斯卡尔-沃利斯检验进行比较。表皮生长因子受体=估计肾小球滤过率;NfL =光神经丝蛋白;P =等离子体。