文摘
摘要目的:评估老龄化如何影响人类大脑的功能连接的关键区域的连接体(即。,hubs), which represent potential vulnerability ‘stations’ to aging, and whether such effects influence the functional and structural changes of the whole brain.
背景:多因子的模型集成老化大脑变量在多个尺度的调查及其与神经退化的关系。
设计/方法:我们招收了128名没有参与者的认知,根据年龄分为两组:50个年轻人(≤35岁)和78名老年人(> 35岁)。在进入研究,两组接受脑部核磁共振成像扫描。我们结合的信息功能连接体脆弱性,通过一个创新的图分析方法研究(逐步功能连通性),老化的大脑皮质萎缩。
结果:首先,研究最优拓扑功能网络组织健康状况(即。,young adults), we observed that fronto-temporo-parietal hubs showed direct functional connectivity with themselves and among each other, while occipital hubs showed direct functional connectivity within occipital regions and sensorimotor areas. Then, modelling cortical thickness changes over lifespan, we observed that fronto-temporo-parietal hubs were among the brain regions that changed the most, whereas occipital hubs showed a quite spared cortical thickness across ages. Finally, cortical regions highly functionally linked to the fronto-temporo-parietal hubs in healthy adults were characterized by the greatest cortical thinning along the lifespan.
结论:我们的研究结果揭示了一个重要的角色的中心连接体拓扑和几何在塑造的生物损伤的积累和分布与老化萎缩,支持假设中心功能连通性重组出现管理区域特定大脑区域的结构改变。
披露:Federica Agosta已收到个人薪酬在500 - 4999美元的范围在飞利浦的演讲人。Federica Agosta已收到个人薪酬在500 - 4999美元的范围作为一个编辑,副主编或编辑顾问委员会成员,爱思唯尔公司Cividini女士没有披露。西尔维亚Basaia没有披露。博士利沃诺主席没有披露。Castelnovo博士没有披露。Leocadi博士没有披露。Elisa Canu的机构已经收到了来自意大利卫生部的研究支持。菲利皮主持博士已经收到个人薪酬在5000 - 9999美元的范围作为顾问拜耳、Idec, Merck-Serono,诺华,罗氏公司,赛诺菲安万特Genzyme,武田和梯瓦制药产业。菲利皮主持博士已经收到个人薪酬在5000 - 9999美元的范围在拜耳的演讲人,Idec, Merck-Serono,诺华,罗氏公司,赛诺菲安万特Genzyme,武田和梯瓦制药产业。菲利皮主持博士已经收到个人薪酬在5000 - 9999美元的范围作为一个编辑,副主编,施普林格自然或编辑顾问委员会成员。 The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, Teva Pharmaceutical Industries, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, and ARiSLA (Fondazione Italiana di Ricerca per la SLA).
