文摘
摘要目的:我们研究脉络丛(CP)在小儿多发性硬化(MS)患者与健康对照组相比(HC),可能与性有关的效应,对临床MRI和结构变量。
背景:CP扩大被建议作为一种可靠的神经炎症标记在成人MS患者,相关措施的大脑结构性破坏和临床残疾。的存在和临床相关性CP扩大在儿科医学患者尚未评估。
设计/方法:大脑3.0 T dual-echo和3 d t1序列回顾性确定从69年儿科患者和23岁女士,sex-matched HC。CP成交量手动从3 d t1扫描获得评级机构由两个专家。
结果:CP分割是高度可再生(intra-observer协议:评定等级I = 0.963,评定等级2 = 0.958;inter-observer协议= 0.968)。HC相比,儿科医学患者显示更高的规范化CP卷(p < 0.001)。当看性别效应,女性和男性都儿科医学患者显示更高的规范化CP体积相比sex-matched HC(女性:p < 0.001;男性:p = 0.021),一个重要的疾病(vs女士HC)性别(女性和男性)交互(p = 0.040)。在MS患者中,高规范化CP成交量明显与更高的大脑T2-hyperintense白质病变(WM)卷(β= 0.252,p = 0.017),较大的侧脑室体积(β= 0.470,富兰克林·德兰诺·罗斯福p < 0.001),低规范化脑容量(β=−0.413,富兰克林·德兰诺·罗斯福p = 0.002)和较低的规范化丘脑的体积(β= 0.291,富兰克林·德兰诺·罗斯福p = 0.046)。没有联想到疾病持续时间、eds得分,规范化的皮质和WM卷被发现(罗斯福p≥0.172)。显著影响疾病的消极关系规范化的CP和花托被发现(罗斯福p = 0.046)。
结论:CP扩张发生在儿科医学患者,建议初期参与疾病的病理生理学。CP量越高,尤其是女性患者,发现支持这一假说的神经炎症过程发生的与性有关的差异已经在儿科医学患者。
披露:莫妮卡Margoni接到MAGNIMS研究支持。Gueye博士没有披露。亚历山德罗代表我没有披露。伊丽莎白帕加尼没有披露。Moiola博士没有披露。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在百时美施贵宝公司的演讲人。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在赛诺菲Genzyme的演讲人。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在诺华的演讲人。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在罗氏的演讲人。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在默克的演讲人。 Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, Teva Pharmaceutical Industries, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, and ARiSLA (Fondazione Italiana di Ricerca per la SLA). Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Bristol Myers Squibb, Celgene, Genzyme, Merck Serono, Novartis, Roche, and Teva. The institution of Maria Assunta Rocca has received research support from Italian Ministry of Health, MS Society of Canada and Fondazione Italiana Sclerosi Multipla.
